Co-clinical Assessment of Tumor Cellularity in Pancreatic Cancer
نویسندگان
چکیده
منابع مشابه
Co-clinical Assessment of Tumor Cellularity in Pancreatic Cancer.
Purpose: Tumor heterogeneity is a hallmark of pancreatic ductal adenocarcinoma (PDAC). It determines tumor biology including tumor cellularity (i.e., amount of neoplastic cells and arrangement into clusters), which is related to the proliferative capacity and differentiation and the degree of desmoplasia among others. Given the close relation of tumor differentiation with differences in progres...
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Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. The genomic landscape of the PDAC genome features four frequently mutated genes (KRAS, CDKN2A, TP53, and SMAD4) and dozens of candidate driver genes altered at low frequency, including potential clinical targets. Circulating cell-free DNA (cfDNA) is a promising resource to detect and monitor molecular character...
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Introduction: The use of DSC-MRI for the assessment of tumor perfusion can be complicated when the blood-brain barrier is leaky, which can result in additional extravascular T2* effects well after the contrast agent (CA) initial bolus has passed through tissue [1]. The resulting DSC-MRI signals are then influenced by the extravascular compartmentalization of CA. We propose that such signals can...
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متن کاملAssessment of cellularity in bone marrow fragments.
Bone marrow cellularity was measured using the Quantimet 720 Image Analyser in 50 biopsy samples. In haematologically normal subjects the percentage cellularity of the marrow was between 40 and 63%. Subjective assessment of cellularity was an unreliable indicator of the quantitative measure.
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2016
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-15-2432